Original Research Articles


2017



Georgiadou M, Lilja J, Jacquemet G, Guzmán C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, Mäkelä TP, Ivaska J (2017) AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol pii: jcb.201609066 [Epub ahead of print]. PMID:28289092


Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J (2017) SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Nat Cell Biol 19(4):292-305. PMID: 28263956


Peuhu E, Kaukonen R, Lerche M, Saari M, Guzmán C, Rantakari P, De Franceschi N, Wärri A, Georgiadou M, Jacquemet G, Mattila E, Virtakoivu R, Liu Y, Attieh Y, Silva KA, Betz T, Sundberg JP, Salmi M, Deugnier MA, Eliceiri KW, Ivaska J (2016) SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. EMBO J 36(2):165-182. PMID: 27974362


2016

Jacquemet G, Baghirov H, Georgiadou M, Sihto H, Peuhu E, Cettour-Janet P, He T, Perälä M, Kronqvist P, Joensuu H, Ivaska J (2016) L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. Nat Commun 7:13297.PMID: 27910855


Rantakari P, Jäppinen N, Lokka E, Mokkala E, Gerke H, Peuhu E, Ivaska J, Elima K, Auvinen K, Salmi M(2016) Fetal liver endothelium regulates the seeding of tissue-resident macrophages.  Nature 538:392-396.  PMID: 27732581


Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J (2016) Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun 7:12237. PMID: 27488962


Cheng F, Shen Y, Mohanasundaram P, Lindström M, Ivaska J, Ny T, Eriksson JE (2016) Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β-Slug signaling.  Proc Natl Acad Sci U S A 113(30):E4320-7. PMID: 27466403


Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robert-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J, Kermorgant S (2016) Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.Nat Commun  7:11942. PMID:27336951

Ratcliffe CD, Sahgal P, Parachoniak CA, Ivaska J, Park M (2016) Regulation of cell migration and β1 integrin trafficking by the endosomal adaptor GGA3. Traffic 17(6):670-88.
PMID: 2693597

De Franceschi N, Arjonen A, Elkhatib N, Denessiouk K, Wrobel AG, Wilson TA, Pouwels J, Montagnac G, Owen DJ, Ivaska J (2016) Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.  Nat Struct Mol Biol 23(2):172-9.
PMID:26779610


2015


De Franceschi N, Peuhu E, Parsons M, Rissanen S, Vattulainen I, Salmi M, Ivaska J, Pouwels J (2015) Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling.  PLoS One 10(11):e0143423. PMID:26600301

Alanko J, Mai A, Jacquemet G, Schauer K, Kaukonen R, Saari M, Goud B, Ivaska J (2015) Integrin endosomal signalling suppresses anoikis.  Nat Cell Biol 17(11):1412-21.
PMID:26436690

Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015) Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα. Dev Cell 34(4):475-83.
PMID:26256210

Virtakoivu R, Mai A, Mattila E, De Franceschi N, Imanishi SY, Corthals G, Kaukonen R, Saari M, Cheng F, Torvaldson E, Kosma VM, Mannermaa A, Muharram G, Gilles C, Eriksson J, Soini Y, Lorens JB, Ivaska J (2015) Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function. Cancer Res 75(11):2349-62.
PMID:25855378

Hakanpaa L, Sipila T, Leppanen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P (2015) Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nat Commun 6:5962.
PMID:25635707

Weber-Boyvat M, Kentala H, Lilja J, Vihervaara T, Hanninen R, Zhou Y, Peränen J, Nyman TA, Ivaska J, Olkkonen VM (2015) OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. Exp Cell Res 29(4):421-36.
PMID:25447204


2014


Muharram G, Sahgal P, Korpela T, De Franceschi N, Kaukonen R, Clark K, Tulasne D, Carpén O, Ivaska J (2014) Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells.  Dev Cell 29(4):421-36. PMID:24814316

Mai A, Muharram G, Barrow-McGee R, Baghirov H, Rantala J, Kermorgant S, Ivaska J (2014) Distinct c-Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1.  J Cell Sci 127(Pt 9):1938-52.
PMID:24790222
 
Eskova A, Knapp B, Matelska D, Reusing S, Arjonen A, Lisauskas T, Pepperkok R, Russell R, Eils R, Ivaska J, Kaderali L, Erfle H, Starkuviene V (2014) An RNAi screen identifies KIF15 as a novel regulator of integrin endocytic trafficking.  J Cell Sci 127(Pt 11):2433-47.
PMID:24659801

Arjonen A, Kaukonen R, Mattila E, Rouhi P, Högnäs G, Sihto H, Miller BW, Morton JP, Bucher E, Taimen P, Virtakoivu R, Cao Y, Sansom OJ, Joensuu H, Ivaska J (2014) Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.  J Clin Invest 24(3):1069–1082.
PMID:24487586


2013


Pouwels J, De Franceschi N. Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg J, Hogg N, Gahmberg CG, Salmi M, Ivaska J (2013) SHARPIN regulates uropod detachment in migrating lymphocytes.  Cell Rep 5:619-28. PMID:24210817

Costa P, Scales TM, Ivaska J, Parsons M (2013) Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion.  PLoS One 8(9):e74659.
PMID:24040310

Hämälistö S, Pouwels J, de Franceschi N, Saari M, Ivarsson Y, Zimmermann P, Brech A, Stenmark H and Ivaska J (2013) A ZO-1/a5b1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin.  PLoS One 88(8):e70696.
PMID:23967087

Högnäs G, Tuomi S, Mattil E, Laine JO, Vilkki V, Murumägi A, Edgren H, Kallioniemi O and Ivaska, J (2013) Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation.  Carcinogenesis 19:2000-2009.
PMID:23689353

Ylilauri M, Mattila E, Nurminen EM, Käpylä J, Niinivehmas SP, Määttä JA, Pentikäinen U, Ivaska J, Pentikäinen OT (2013) Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone.  Biochim BiophysActa 1834:1988-97.
PMID:23856547


2012


Sandri C, Caccavari F, Valdembri D, Camillo C, Veltel S, Santambrogio M, Lanzetti L, Bussolino F, Ivaska J, Serini G (2012) The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling.  Cell Res 10:1479-1501. PMID:22825554

Virtakoivu R, Pellinen T, Rantala JK, Perälä M and Ivaska J (2012) Distinct roles of AKT isoforms in regulating β1-integrin activity, migration and invasion in prostate cancer.  Mol Biol Cell 17:3357-3369.
PMID:22809628

Pellinen T, Rantala JK, Arjonen A, Mpindi JP, Kallioniemi O and Ivaska J (2012) A functional genetic screen reveals new regulators of β1-integrin activity.  J Cell Sci 125:649-661.
PMID:22389402

Arjonen A, Alanko J, Veltel S, Ivaska J (2012) Distinct Recycling of Active and Inactive β1 Integrins.  Traffic 13:610-25.
PMID: 22222055

Rintanen N, Karjalainen M, Alanko J, Paavolainen L, Mäki A, Nissinen L, Lehkonen M, Kallio K, Cheng RH, Upla P, Ivaska J and Marjomäki V (2012) Calpains promote α2β1 integrin turnover in non-recycling integrin pathway.  Mol Biol Cell 23:448-463.
PMID:22160595

Högnäs G, Tuomi S, Veltel S, Mattila E, Murumägi A, Edgren H, Kallioniemi O and Ivaska J (2012) Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.  Oncogene 31:3597-3606.
PMID: 22120710


2011


Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, Potter C, Duffy T, Sundberg JP, Askari JA, Humphries M, Kallioniemi O, Parsons M, Salmi M. and Ivaska J (2011) Sharpin is an endogenous inhibitor of beta1-integrin activation.  Nat Cell Biol 13:1315-1324.
PMID:21947080

Mai A, Veltel S, Pellinen T, Padzik A, Coffey E, Marjomäki V and Ivaska J (2011) Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor trafficking in migrating cancer cells.  J Cell Biol 194:291-306.
PMID:21768288

Vuoriluoto K, Högnäs G, Meller P, Lahti K and Ivaska J (2011) Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP.  Matrix Biology 30:207-217.
PMID:21414405

Vuoriluoto K, Haugen H, Kiviluoto S, Mpindi JP, Nevo J, Gjerdrum C, Lorens JB and Ivaska J (2011) Vimentin regulates EMT induction and migration by governing Axl expression in breast cancer.  Oncogene 330:1436-1448.
PMID:21057535


2010


Plantard, L. Arjonen, A, Lock, J.G, Nurani, G, Ivaska J and Strömblad S (2010) PtdIns(3,4,5)P3 is a regulator of Myosin-X localization and filopodia formation. J Cell Sci 123:3525-34.
PMID:20930142

Nevo J, Mai A, Tuomi S, Pellinen T, Pentikäinen OT, Heikkilä P, Lundin J, Joensuu H, Bono P. and Ivaska J (2010) Mammary derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion.  Oncogene 29:6452-63.
PMID:20802519

Vihinen PP, Hernberg M, Vuoristo MS, Tyynelä K, Laukka M, Lundin J, Ivaska J, Pyrhönen S. (2010) A phase II trial of bevacizumab with dacarbazine and daily low-dose interferon-alpha2a as first line treatment in metastatic melanoma.  Melanoma Res 20:318-25.

Mattila E, Marttila H, Sahlberg N, Kohonen P, Tahtinen S, Halonen P, Perala M, Ivaska J (2010) Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase.  BMC Cancer 10(1):7.
PMID:20055993


2009


Nevo J, Mattila E, Pellinen T, Yamamoto DL, Sara H, Iljin K, Kallioniemi O, Bono P, Joensuu H, Wärri A and Ivaska J (2009) Mammary-derived growth inhibitor alters traffic of EGFR and induces a novel form of cetuximab resistance.  Clin Cancer Res 15:6570-6581.
PMID:19825952

Côme C, Laine A, Chanrion M, Edgren H, Mattila E, Liu X, Jonkers J, Ivaska J, Isola J, Darbon J, Kallioniemi O, Thézenas S and Westermarck J (2009) CIP2A is associated with human breast cancer aggressivity.  Clin Cancer Res 15: 5092-5100.
PMID:19671842

CTuomi S, Mai A, Nevo J, Laine JO, Vilkki V, Öhman TJ, Gahmberg CG, Parker PJ and Ivaska J (2009) PKCε Regulation of an α5 Integrin–ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells.  Sci Sig 2(77): ra32.
PMID:19567915

Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P and Grosse R (2009) SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin.  Nat Cell Biol 11(5):557-68.
PMID:19350017


2008


Mattila E, Koskinen K, Salmi M. and Ivaska J (2008) Protein tyrosine phosphatase TCPTP controls VEGFR-2 signalling.  J Cell Sci 121:3570-80. PMID:18840653

Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A and Zent R (2008) Crosstalk between integrins α1β1 and α2β1 in renal epithelial cells.  Exp Cell Res 1314:3593-604.
PMID:18809396

Vuoriluoto K, Jokinen J, Salmivirta M, Heino J and Ivaska J (2008) Syndecan-1 supports integrin α2β1 mediated adhesion to collagen.  Exp Cell Res 314:3369-81.
PMID:18657535

Lehto M, Mäyräpää MI, Pellinen T, Ihalmo P, Lehtonen S, Kovanen PT, Groop PH, Ivaska J and Olkkonen VM (2008) A novel R-Ras interaction partner, OSBP related protein 3 (ORP3), regulates cell adhesion.  J Cell Sci 121:695-705.
PMID:18270267


2004-2007


Vihinen P, Kallioinen M, Vuoristo MS, Ivaska J, Syrjänen KJ, Hahka-Kemppinen M, Kellokumpu-Lehtinen PL, Pyrhönen SO (2007) Serum angiogenin levels predict treatment response in patients with stage IV melanoma.  Clin Exp Metastasis 24:567-74. PMID:17762972

Junttila MR, Puustinen P, Niemelä M, Ahola R, Nielsen C, Kallunki T, Ivaska J, Arnold H, Lu SL, Wang XJ, Kähäri VM, Westermarck J (2007) CIP2A inhibits PP2A in Human Malignancies.  Cell 130:51-62.
PMID:17632056

Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J (2006) Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.  J Cell Biol 173:767-80.
PMID:16754960

Ivaska J, Vuoriluoto, K, Huovinen, T, Izawa, I, Inagiki, K, and Parker, PJ (2005) PKCε mediated phosphorylation of vimentin controls integrin recycling and motility.  EMBO J 24:3834-3845.
PMID:16270034

Mattila E, Pellinen T, Nevo J, Vuoriluoto K, Arjonen A and Ivaska J (2005) Negative regulation of EGFR signalling via integrin α1β1-mediated activation of protein tyrosine phosphatase TCPTP.  Nat Cell Biol 7:78-85.
PMID:15592458

Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris R.C, Pozzi A and Zent R. (2004) Differential expression of collagen and laminin binding integrins mediate ureteric bud and inner medullary collecting duct cell tubulogenesis.  Am J Physiol-Renal 287:F602-11.
PMID:15187002

Jokinen J, Dadu E, Nykvist P, Käpylä J, White DJ, Ivaska J, Vehvilainen P, Reunanen H, Larjava H, Hakkinen L, Heino J (2004) Integrin mediated cell adhesion to type I collagen fibrils. J Biol Chem 279:31956-31963.
PMID:15145957


Upla P, Marjomäki V, Kankaanpää P, Ivaska J, Hyypiä T, van der Goot FG and Heino J (2004) Clustering induces a lateral redistribution of α2β1 integrin from membrane rafts to caveolae and subsequent PKC-dependent internalization.  Mol Biol Cell 15:625-636. PMID:14657242

Turku Centre for Biotechnology

University of Turku

IVASKA LAB

Cell Adhesion and Cancer