Copyright © Johanna Ivaska. All rights reserved.
Research Interests in Brief
Integrins and receptor tyrosine kinases (RTKs) are cell surface receptors regulating key cellular processes such as survival, proliferation and migration. The loss or perturbation of mechanisms that would normally confer tight control over these receptors is associated with a number of diseases including cancer. Current projects in the Ivaska lab are concerned with understanding how the activity and endo/exosomal trafficking of these receptors, and receptor crosstalk, contribute to the different steps of cancer progression. We are also investigating how cancer cells sense their microenvironment and how the biophysical cues from the tumour stroma determine cancer cell fate.
Our projects receive funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no. 615258 and from the Academy of Finland, the Cancer Society of Finland and the Sigrid Juselius Foundation.